Today's major industrial XR players are non-European. Despite Europe's strong scientific base in XR, the industry faces challenges like market fragmentation, insufficient investment, and difficulties in commercializing research. INDUX-R aims to transform European industries with a human-centric XR ecosystem, addressing challenges with breakthroughs in core XR technologies. Its use cases span various industrial ecosystems, promoting a human-centric approach to XR technology development and addressing societal and ethical challenges. INDUX-R envisions a legal and ethical framework aligned with European values for XR technological development. The breakthrough on core XR technologies, that will be implemented in INDUX-R include digitisation and creation of XR assets, realistic animation, light-field HMDs, XR media streaming and egocentric perception. To address challenges that multi-user XR applications pose, INDUX-R will implement a highly scalable, zero-touch 5G architecture and a secure, interoperable IoT network that can accommodate fluctuating demands and minimize waste of resources. The foreseen use cases cover a wide spectrum of industrial ecosystems in event planning, Industry 4.0 virtual medical training, cultural tourism, and broadcasting of sports events where end-users will participate in every step of INDUX-R, from the elaboration of user requirements up to final qualification of the ecosystem, thus implementing a human-centric approach of XR technology development. In this regard, INDUX-R reflects upon the societal and ethical challenges that XR poses, building a legal and ethics framework that will ensure that technological development is aligned with European values.