Implementation of Electronic Health Records (EHR) at a national level constitutes a radical innovation for health care. Along with technical challenges, EHR implementations face several political, social and organizational issues which are often overlooked. Acknowledging that EHR success needs to engage all stakeholders, manage organizational changes and alleviate resistance, EHR-IMPLEMENT aims to examine political, social and organizational factors influencing large scale EHR implementations, and identify best practices. Through a case study approach the project will perform an in-depth comparison and assessment of six national EHR initiatives, and will conduct a focused survey on EHR implementation strategy and actions on European level. Overall, EHR-IMPLEMENT will engage high level scientific experts and national authorities into knowledge exchanges, and formulate recommendations facilitating the dissemination of EHR in the European Members and Associated States and assisting the European Union in achieving its eHealth objectives.